Saturday, August 1, 2020

Ivermectin vs. COVID-19

This is a collection of links I've accumulated about the drug Ivermectin and its use against COVID-19.  This drug is safe, cheap (patent-expired), widely available, FDA approved for many uses, classified by the WHO as "essential medicine", and extremely effective against SARS-CoV-2 and COVID-19.  Ivermectin has even proven to be effective against cancer. One can only speculate as to why the media has not picked up on this.

This page will be updated as new information comes in.

In vitro Study

This is the study that started it all.  Ivermectin was found to kill "essentially all" of the virus in just 48 hours in vitro.  The second link is some criticism of the study's dosage requirements and the author's response.

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses 

Clinical Trials

List of Ivermectin clinical trials

EU list of Ivermectin clinical trials

Completed trials 

Azithromycin with nitazoxanide, hydroxychloroquine or ivermectin, with or without dutasteride, for early stage COVID-19: an open-label prospective observational study in males with mild-to-moderate COVID-19 (The Pre-AndroCoV Male Trial).



Ivermectin treatment may improve the prognosis of patients with COVID-19 

COVID-19: IVERMECTIN PROPHYLAXIS IN ADULT CONTACTS. First Report on Health Personnel and Post-Exposure Prophylaxis

USEFULNESS of Topic Ivermectin and Carrageenan to Prevent Contagion of Covid Among Healthy People and Health Personnel (English translation)

Use of Ivermectin as a Prophylactic Option in Asymptomatic Family Close Contacts with Patients of COVID-19

 PDF

Therapeutic Efficacy of Ivermectin as an Adjuvant in the Treatment of Patients with COVID-19

A Randomized Trial of Ivermectin-Doxycycline and Hydroxychloroquine-Azithromycin therapy on COVID19 patients.

ICON (Ivermectin in COvid Nineteen) study: Use of Ivermectin is Associated with Lower Mortality in Hospitalized Patients with COVID19

Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management (Pilot Trial)

A Case Series of 100 COVID-19 Positive Patients Treated with Combination of Ivermectin and Doxycycline 

Comparison of Viral Clearance between Ivermectin with Doxycycline and Hydroxychloroquine with Azithromycin in COVID-19 Patients

COVID-19 Papers




Ivermectin: an award-winning drug with expected antiviral activity against COVID-19

Ivermectin, Famotidine, and Doxycycline: A Suggested Combinatorial Therapeutic for the Treatment of COVID-19

Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?

Ivermectin & Orthomolecular Medicine Combination Therapy for COVID-19: Successful Clinical Protocols and A Case Study

Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2

Ivermectin: A Closer Look at a Potential Remedy

Ivermectin as a promising RNA-dependent RNA polymerase inhibitor and a therapeutic drug against SARS-CoV2: Evidence from in silico studies

Self-medication during COVID-19 outbreak: a cross sectional online survey in Dhaka city

COVID-19: THERAPEUTIC PLAN AND POTENTIAL THERAPIES. Version as of September 4, 2020

Nebulized ivermectin for COVID-19 and other respiratory diseases, a proof of concept, dose-ranging study in rats

Ivermectin: Potential Role as Repurposed Drug for COVID-19

HIV-1 versus SARS-CoV-2 infection: understanding the population genetic aspects of drug inefficacy (especially ivermectin) in the integrase-importin complex

Antiviral Activity of Ivermectin Against SARS-CoV-2: An Old-Fashioned Dog with a New Trick—A Literature Review

White paper on Ivermectin as a potential therapy for COVID-19

Effective Anti-SARS-CoV-2 RNA Dependent RNA Polymerase Drugs Based on Docking Methods : The Case of Milbemycin, Ivermectin, and Baloxavir Marboxil

Has Ivermectin Virus-Directed Effects against SARS-CoV-2? Rationalizing the Action of a Potential Multitarget Antiviral Agent

Current status and strategic possibilities on potential use of combinational drug therapy against COVID-19 caused by SARS-CoV-2 

Potential use of hydroxychloroquine, ivermectin and azithromycin drugs in fighting COVID-19: trends, scope and relevance

A comprehensive review on epidemiology, aetiopathogenesis, diagnosis and treatment of the novel coronavirus syndrome – COVID-19

Molecular Docking and Molecular Dynamic Study of two Viral Proteins associated with SARS-CoV-2 with Ivermectin

Nsp7 and Spike Glycoprotein of SARS-CoV-2 are envisaged as Potential Targets of Vitamin D and Ivermectin

Ivermectin for COVID-19 Treatment: Clinical Response at Quasi-Threshold Doses Via Hypothesized Alleviation of CD147-Mediated Vascular Occlusion

Evaluation of diversity levels in HIV-1 virus integrase gene sequences, supporting the lack of target specificity of ivermectin versus the integrase-importin complex in SARS-CoV-2 inflection

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

The broad spectrum antiviral ivermectin targets the host nuclear transport importinα/β1 heterodimer

Ivermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2

Hydroxychloroquine and ivermectin: A synergistic combination for COVID-19 chemoprophylaxis and treatment?

A Combination of Ivermectin and Doxycycline Possibly Blocks the Viral Entry and Modulate the Innate Immune Response in COVID-19 Patients

A Wonder Drug in the Arsenal against COVID - 19: Medication Evidence from Ivermectin

Antimalarials for COVID-19 Treatment: Rapid Reversal of Oxygen Status Decline with the Nobel Prize-Honored Macrocyclic Lactone Ivermectin

Battle against Coronavirus: Repurposing old friends (Food borne polyphenols) for new enemy (COVID-19)

Ivermectin, a new candidate therapeutic against SARS-CoV-2/COVID-19 

Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen.  

Ivermectin: potential candidate for the treatment of Covid 19

Coronavirus (2019-nCoV) Deactivation via Spike Glycoprotein Shielding by Old Drugs, Bioinformatic Study

Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action

An Overview of Possible Therapeutic Approaches Against Novel Coronavirus Disease 2019 Pandemic

Binding Mechanism and Structural Insights into the Identified Protein Target of Covid-19 with In-Vitro Effective Drug Ivermectin

Ivermectin: repurposing a multipurpose drug for Venezuela's humanitarian crisis

Repurposing Ivermectin to inhibit the activity of SARS CoV2 helicase: possible implications for COVID 19 therapeutics

Repurposing approved drugs as inhibitors of SARS-CoV-2 S-protein from molecular modeling and virtual screening

Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): a global pandemic and treatment strategies.

COVID-19 Infections and Africa: Why Do the African Countries Show the Least Number of Cases?

Mass Drug Administration and Worms Experience in Africa: Envisage Repurposing Ivermectin for SARS-COV-2

Ivermectin for Covid-19

The Battle against COVID 19 Pandemic: What we Need to Know Before we “Test Fire” Ivermectin

Ivermectin for COVID-19: A living systematic review protocol

Continuous high-dose ivermectin appears to be safe in patients with acute myelogenous leukemia and could inform clinical repurposing for COVID-19 infection

Ivermectin as a Potential Therapeutic Agent for COVID-19 – case studies

COVID-19 DE LARGA DURACIÓN: TRATAMIENTO CON IVERMECTINA DE PACIENTES CON SINTOMASPERSISTENTES

Combating COVID-19 Pandemic in Bangladesh: A Memorandum from Developing Country

Proposal To Halt The COVID-19 Pandemic With Ivermectin

Papers on other diseases

SILAC quantitative proteomics analysis of ivermectin‐related proteomic profiling and molecular network alterations in human ovarian cancer cells

Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer  

Advancements in Host-Based Interventions for Influenza Treatment

Inhibition of human adenovirus replication by the importin α/β1 nuclear import inhibitor ivermectin

Serious Neurological Adverse Events after Ivermectin—Do They Occur beyond the Indication of Onchocerciasis?

Ivermectin reduces alcohol intake and preference in mice

Blogs

Gustavo A. Aguirre Chang; Médicoegresado de la UNMSM. Perú.

Usefulness of Ivermectin in COVID-19 Illness - José L. Segovia Juárez, Ph.D

Ivermectin for COVID-19

Gold Standard: Ivermectin Protocol

Ivermectin

News Articles   

Dr. Paul Marik: Ivermectin Works and Should be Accepted for Large Observational Studies

MedinCell Initiates the First Clinical Trial of Its Covid-19 Prevention Program

ICON Study Evidencing Efficacy of Ivermectin Against COVID-19 Published in Peer Review Journal Chest

RESULTS POSITIVE OF THE PROTOCOL IVER.CAR IN THE PROPHYLAXIS OF THE AGENTS OF HEALTH

Doctors cure 6,000 patients with Covid-19 with Ivermectin

New Proteomics Analysis May Show How Ivermectin Fights COVID-19

Peer-Reviewed Results of Bangladesh Medical College Prospective Study: Ivermectin & Doxycycline Combination Effectively Treats Mild to Moderate COVID-19



An Old Drug Tackles New Tricks: Ivermectin Treatment in Three Brazilian Towns

Ivermectin treatment 'could bring us all together by Christmas'

Southern California Research Institute Receives FDA Greenlight for Ivermectin Clinical Trial

Ivermectin Moves Towards Mainstream


Read more here: https://www.miamiherald.com/news/local/community/florida-keys/article245313450.html#storylink=cpy

Zagazig University Randomized Controlled Ivermectin Study Results Confirms PI Hypothesis: Drug Effective Against COVID-19

Lucknow admin to set up kiosks for distribution of Ivermectin tablets

Merck: Ivermectin Triple Therapy Protocol for COVID-19 Released to Australian GPs for Infected Elderly and Frontline Workers

Topelia Therapeutics Leading Studies to Commercialize Ivermectin Targeting COVID-19 Infection

Ivermectin Breaking into American News as Doctors Come Forward & Share Treatments for COVID-19

Ivermectin to be used for Covid treatment in UP to replace hydroxychloroquine 

Australian Triple Therapy for COVID-19: 'Wonder Drug' Ivermectin in a Triple Therapy Should be Used for COVID-19 Cure and Prevention in Victoria says Professor who Developed Peptic Ulcer Cure

Brazilian Ivermectin sales in June surpass entire 2019 figures

UP govt directs use of drug Ivermectin for treatment of COVID-19 patients, to replace HCQ 

Ivermectin tablet effective in prevention and treatment of corona - Additional Chief Secretary Health released GO

Johns Hopkins to Conduct an Ivermectin Study with Hospitalized Patients Infected with COVID-19

Dr Tarek Alam: Unleashing the potential of Ivermectin

Broward County Doctor Using Ivermectin Off-Label Combo on COVID-19 Patients—It is Working & Secures County Health Protocol Approval

Bangladesh begins ivermectin trial in COVID-19 patients

Bangladesh doctors claim to have found effective drug combination to cure COVID-19 patients

Bangladesh Medical Team Claims Ivermectin With Doxycycline Clears COVID-19

Ivermectin is a winner treating Covid-19 patients in DR

Age-old drug to rein in corona?

Tanta University PI Sponsors Ivermectin Studies Targeting COVID-19 in up to 160 Patients While Safety is a Concern for Regulators

New Study to Assess the Efficacy of Ivermectin Against COVID-19

In Pursuit of Real-World Ivermectin Stories: Tales from Pathanamthitta

University of Kentucky launches clinical trial to look at new ways to treat COVID-19

After 48 days of treatment, Shirley defeats COVID-19

Israeli researcher: Antiparasitic drug could 'cure' coronavirus

MedinCell: Adapt and overcome in response to the Covid-19 crisis

Mexican Hospital Starts Clinical Trial Testing Ivermectin in Serious, Non-Critical Hospitalized COVID-19 Patients

Mexican Federal Government Commences Ivermectin Clinical Trials Targeting COVID-19

Breakthrough Drug: Ivermectin Shows 'Astounding' Results Against Coronavirus

Professor William Campbell, who shared a Nobel Prize for his role in the discovery of Ivermectin has been sharing his thoughts on the major developments

How a Grass Roots Health Movement Led to Acceptance of Ivermectin as a COVID-19 Therapy in Peru

Peru: University students produce ivermectin for COVID-19 patients

What happened in Iquitos (Peru)?

Antiparasitic drug ivermectin reduces coronavirus fatality rate: American researchers

President of Dominican Republic’s Largest Private Health Group Discusses the Success of Ivermectin as a Treatment for Early Stage COVID-19

Ivermectin Study Reveals Fantastic Results: 100% of 60 Patients Better in an Average of Just Under 6 Days

Head lice drug ivermectin being studied as possible coronavirus treatment

Effective formula knocks out Covid-19 in the Peruvian Amazon

Honduras president stable, fatigued after hospitalization

Taiwan and Australia Jointly Develop New Anti-novel Coronavirus Drugs

Bolivian Region Authorizes Ivermectin as Treatment Against COVID-19

Why Bolivia authorized an animal dewormer to treat patients with covid-19 – PrensaLibre

Bolivian city gives out free doses of de-worming drug in bid to combat coronavirus

Corona patients will be treated with De Warming's medicine!

Japan to revise criteria on symptoms for being tested for virus

Japan Poised to Quickly Approve Futhan, Actemra, Ivermectin for COVID-19 IfEffective: Abe

Videos  

Dr. Paul Marik - COVID-19: Ivermectin Update

Professor Thomas Borody Interview – Part 2

There is no good reason to ban two potential ‘COVID cures’

Australian researchers tout new 'wonder drug' as potential cure for coronavirus patients

Australia’s spirits have ‘been crushed’ by its COVID-19 response: Alan Jones 

Preliminary Ivermectin study covid-19 (Argentina) 

Ivermectin and COVID-19 Management with Adam Gaertner

Discussion: Ivermectin for COVID-19 

Herald Sun - Ivermectin treatment is a ‘real killer of coronavirus’

Dr. Jean-Jacques Rajter and Dr. Juliana Cepelowicz Rajter Discuss Ivermectin In Broward Country

COVID19 Ivermectin-Saved lives in Toronto Nursing Home. Pandemic Protection-Turning Point?

Ivermectin effect in covid deaths in Peru. Chilean TV (English subtitles)

Ivermectin, Heparin, and COVID-19: An Interview with Dr. David Scheim

Ivermectin: COVID 19 Protection from the front line.

Ivermectin And COVID-19: Ivermectin Efficacy, Blood Clotting, The CD147 Receptor, And More.

“I'm really impressed by IVERMECTIN (...) I'm thinking about adding that on the protocol" Dr Vladimir Zelenko

Reddit

https://www.reddit.com/r/ivermectin/

Successful treatment of tocilizumab and ivermectin for a patient with ARDS due to COVID-19 (Taiwan 2020-09-30) Case study (PDF)

Phase II study on chloroquine and hydroxychloroquine in patients with manifestations serious cases of COVID-19 infection (Brazil 2020-09-27) New trial!

A randomized double-blind placebo-controlled trial of oral ivermectin outpatient treatment, to prevent hospitalisation, of those at high risk for hospitalization due to SARS-CoV-2 (COVID-19) (Australia 2020-10-07) New trial!




 

8 comments:

Administrator said...

Thank you for sharing this. You are awesome!

Liberteur said...

You're welcome.

Anonymous said...

Great collection of sources. Thank you!

Liberteur said...

You are welcome. Thanks for the comment.

Anonymous said...

Much gratitude foe this. I will share this far and wide. Thank you for taking the time to make it simple to share this data. We have Dr Barody in Australia advocating for but no trials here yet :)

Liberteur said...

Happy to do it. And glad you’re getting the word out! We won’t get any help from the media, that’s for sure.

Alphonse said...

Thanks for posting some https://www.reddit.com/r/ivermectin/ links! More eyeballs is better.

I think it's my turn to mine your blog for links. :)

Liberteur said...

Mine away Alphonse! Like you said, the more eyes the better.