Ivermectin vs. Cancer

This page grew out of my Ivermectin vs. COVID-19 page.  While collecting links on that subject I ran across these papers on ivermectin and cancer.

The drug shows some amazing potential as a safe, non-toxic, treatment that can be used as an alternative, or addition, to chemotherapy.

Papers

Cancers in general.

Repurposing Vermicide Ivermectin as Medicine in Oncology to Treat Cancer- The Silent but Accessible Role Player in Sustainable Innovation

Inhaled Ivermectin-Loaded Lipid Polymer Hybrid Nanoparticles: Development and Characterization

Ivermectin and its synthetic derivatives – A new class of anticancer agents

Ivermectin: A Multifaceted Drug With a Potential Beyond Anti-parasitic Therapy

Ivermectin A Potential Repurposed Anti-Cancer Therapeutic

Ivermectin: The future of Cancer Treatment

Outcome of Ivermectin in Cancer Treatment: An Experience in Loja-Ecuador

Ivermectin inhibits tumor metastasis by regulating the Wnt/β-catenin/integrin β1/FAK signaling pathway

Ivermectin Enhanced Antitumor Activity of Resiquimod in a Co-loaded Squalene Emulsion

Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy

Synergistic Anti-tumor Effect of Dichloroacetate and Ivermectin

Ivermectin: Potential Repurposing of a Versatile Antiparasitic as a Novel Anticancer

Ivermectin, a potential anticancer drug derived from an antiparasitic drug

Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin

The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT‐TCF pathway responses in human cancer

Ivermectin inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor models

Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug

Inhibition of TMEM16A Ca2+-activated Cl− channels by avermectins is essential for their anticancer effects

Ivermectin kills cancer cells via catastrophic changes in the endoplasmic reticulum structure

Old wine in new bottles: Drug repurposing in oncology

Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells

Lung cancer

Ivermectin induces nonprotective autophagy by downregulating PAK1 and apoptosis in lung adenocarcinoma cells

Multiple myeloma

Assessing the potential of ivermectin against t(4;14) multiple myeloma.

Combinations of ivermectin with proteasome inhibitors induce synergistic lethality in multiple myeloma

Pancreatic cancer

Ivermectin suppresses pancreatic cancer via mitochondria dysfunction

Prostate cancer

Eprinomectin: a derivative of ivermectin suppresses growth and metastatic phenotypes of prostate cancer cells by targeting the β-catenin signaling pathway

Integrated analysis reveals FOXA1 and Ku70/Ku80 as direct targets of ivermectin in prostate cancer

Breast cancer

Ivermectin Synergizes with Modulated Electro-hyperthermia and Improves Its Anticancer Effects in a Triple-Negative Breast Cancer Mouse Model